London Covid: Can I get infected twice? And will a fourth booster be needed?
If I had the Delta variant, am I less likely to get Omicron? There have been many reports of people getting infected during the Delta wave (around summer 2021) and then again during the Omicron wave (from November 2021). As we know, the Omicron variant has substantial mutations on the spike protein, meaning it cam somewhat evade immunity from previous infection or vaccination. Research in December from Imperial College London estimated that the risk of reinfection with the Omicron variant is 5.4 times greater than that of the Delta variant.
As the COVID pandemic has progressed, we’ve repeatedly seen the arrival of new viral variants. Variants of concern, such as delta and omicron, are versions of SARS-CoV-2 (the virus that causes COVID-19) which have acquired mutations. These mutations can provide SARS-CoV-2 with a genetic advantage – so for example, delta is linked to more serious illness than the original Wuhan strain, while omicron is more infectious.
Now we are seeing recombinant variants such as omicron XE. These are not viruses which have picked up a few mutations. Instead, they are viruses containing a combination of genetic material from multiple variants, producing a new version of the SARS-CoV-2 virus.
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Omicron has been shown to typically cause less serious illness, but also brings with it an increased risk of reinfection . A study published by the World Health Organisation (WHO) and Imperial College London in December showed Omicron is five times more likely to reinfect people than the previously dominant Delta variant. Analysis by the UK Health Security Agency (UKHSA) published in December showed that around one in 10 people with the Omicron variant in England had previously contracted Covid-19.
So far there have been at least 1,179 cases of omicron XE identified in the UK (this was the figure in the most recent update from the UK Health Security Agency published on April 8). The majority of these cases have been in the south and east of England. There have also been reports of a handful of cases elsewhere around the world, likely due to international travel.
So how worried should we be about omicron XE? While we don’t know a lot about it yet, what we do know doesn’t suggest there’s cause for serious concern. Let’s take a look.
A bit about recombinant variants
When viruses replicate, they sometimes make mistakes in their genetic code leading to individual mutations. Often, these mutations don’t result in any change to the structure of the virus – termed “ silent mutations ”. Some mutations, however, can confer an advantage. For example, mutations that occur in the spike protein (the part of SARS-CoV-2 responsible for infecting our cells) can make the virus more transmissible than previous variants. We’ve seen repeated mutations in the spike protein producing variants of concern.
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Recombination is a different process, whereby two different variants infect the same cell, in the same person, at the same time. From there, they can combine their genetic material, resulting in a virus that possesses a mix of genes from both infecting “parent” viruses. This recombinant variant may then spread to other people – as has been the case with omicron XE. © Provided by Wales Online A diagram depicting the process of recombination versus replication.
Recombination occurs when two different variants infect the same cell at the same time. Grace C. Roberts , Author provided
In fact, multiple recombinant variants have been identified globally by PANGOLIN (the SARS-CoV-2 lineage surveillance carried out by the COVID-19 genetics UK consortium). At least three of these – XD, XE and XF – have been detected in the UK.
Some recombinants, such as XD and XF, are combinations of the delta variant with omicron lineages. You might have heard of these hybrids, which have been dubbed “ deltacron ”. XE, however, is a combination of two omicron strains: BA.1 and BA.2.
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Why do different variants combine?
Genetic recombination of viruses is not a new phenomenon. It occurs regularly with viruses such as influenza and HIV. Indeed, one of the proposed origins of the original Wuhan SARS-CoV-2 virus is from a recombination event in bats.
From an evolutionary perspective, recombination offers viruses an advantage, as it allows more rapid and significant changes to the virus, compared with the slower process of acquiring mutations through errors in replication. Recombinant viruses can exhibit marked changes in their behaviour, such as increased infectiousness, evasion of our existing immunity to the virus, or resistance to drugs. Much like error-based mutation, however, some recombinant viruses show no apparent differences to their parent viruses.
We know that omicron XE has the majority of its genetic information, including the spike protein, from the omicron sub-variant BA.2, which is the variant predominating in the UK at the moment. It is likely, therefore, that the characteristics of omicron XE (such as transmissibility, severity of disease and vaccine efficacy) are similar to those of BA.2. But it’s prudent that scientists continue to monitor and study omicron XE, as it is a genetically distinct virus from its parents.
New Omicron wave 'has already peaked', says expert
On Friday, data from the Office for National Statistics (ONS) showed one in 16 people in England and Wales - and one in 11 in Scotland - currently have Covid-19.Paul Hunter, professor of infectious diseases at the University of East Anglia, said the highly infectious BA.2 variant of Omicron was quickly running out of people to infect, but medics cautioned that in the short term at least, Covid-related hospitalisations and deaths could rise further.
Initial data for the omicron XE variant suggests that the growth rate (that is, the proportion of new infections in the population) is slightly higher than that of omicron BA.2. However, because there are only a small number of infections with XE at present, the data we have on this is limited and it’s difficult to draw solid conclusions for now.
Reassuringly, we know that BA.2 is no more severe than BA.1, and that omicron variants overall tend to cause less severe disease than previous SARS-CoV-2 variants. But they are highly infectious.
The need for updated vaccines is becoming ever-pressing since all current vaccines are based on the original Wuhan strain. Data has shown that the more changes in the spike protein subsequent variants have acquired, the less effective our current vaccines are at preventing infection. That said, vaccines are still very effective at preventing severe disease or death from COVID.
Of course, we need more research to understand the characteristics of this new omicron XE strain. But it appears, at present, to be very similar to the current circulating strains of SARS-CoV-2. As we well know, it’s not the first variant of the virus, and it’s highly unlikely to be the last.
Grace C Roberts, Research Fellow in Virology, University of Leeds
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Omicron XE key symptoms explained by leading immunologist - best way to spot signs .
OMICRON XE is responsible for more than 1,100 confirmed Covid infections in England so far, with further cases expected to rise. Express.co.uk spoke to leading immunologist, Denis Kinane to find out more about the key symptoms to look for.COVID-19 cases are continuing to climb across the country, despite the end of the free testing regime making infections harder to track. Generic symptoms are making the existing variants even harder to tell apart from the common cold or influenza virus, but is the latest Omicron XE recombinant any different? These are the known symptoms of Omicron XE according to Denis Kinane, leading Immunologist and Founding Scientist of Cignpost Diagnostics.