Sport: NFL odds, lines, picks, spreads, best bets, predictions for Week 12, 2021: Model backing Steelers, Patriots

One of the best things about Thanksgiving is the leftovers, and after Thursday's tripleheader, there are still plenty of intriguing games left on the Week 12 NFL schedule. The surging Indianapolis Colts are three-point underdogs to Tom Brady and the Tampa Bay Buccaneers in the latest NFL odds on Caesars Sportsbook. Later, Cam Newton will try to build off of last week's impressive return to Carolina as a two-point favorite against the Miami Dolphins, per the latest NFL spreads.

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San Francisco 49ers tight end George Kittle (85) during Super Bowl LIV against the Kansas City Chiefs at Hard Rock Stadium.

NFL Week 11 picks, plus Antonio Brown's vaccination controversy and recapping Patriots' blowout win in Atlanta

Here's everything you need to know about the NFL for Nov. 19SEATTLE, WASHINGTON - OCTOBER 07: Quarterback Russell Wilson #3 of the Seattle Seahawks passes against the Los Angeles Rams in the first half at Lumen Field on October 07, 2021 in Seattle, Washington.

Which other NFL matchups offer the best value when looking for the top Week 12 NFL bets and NFL predictions? All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

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FFT 11/19

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

One of the model's strongest Week 12 NFL picks is that the Steelers (+3.5) cover the spread against the Bengals. The Bengals are coming off of a win against the wayward Las Vegas Raiders, but their offense has been trending the wrong direction over their last three games. Cincinnati should look to make running back Joe Mixon the focal point of its offense this week, as Pittsburgh has allowed 524 rushing yards over its last three games.

SportsLine's model predicts that Mixon will only come away with 74 yards, while Bengals quarterback Joe Burrow will throw as many interceptions as touchdowns in the game. That's not a recipe for margin, and the model projects that Pittsburgh keeps the score within a field goal in almost 60 percent of simulations.

Chargers vs. Steelers odds, spread: Sunday Night Football picks, predictions from NFL model on 128-89 run

SportsLine's model simulated Pittsburgh Steelers vs. Los Angeles Chargers on SNF 10,000 timesTAMPA, FLORIDA - OCTOBER 04: Justin Herbert #10 of the Los Angeles Chargers looks to pass during the third quarter of a game against the Tampa Bay Buccaneers at Raymond James Stadium on October 04, 2020 in Tampa, Florida.

Another one of its Week 12 NFL predictions: The Patriots (-7) cover against the Titans. The Patriots are the hottest team in the NFL, rattling off five consecutive wins coming into this week's game. They opened as 2.5-point home favorites, but are now seven-point favorites following Tennessee's shocking loss to Houston. The Titans were unable to overcome a four-interception game from quarterback Ryan Tannehill, who will be without his top two receivers.

New England's defense has allowed an average of just 169.6 passing yards per game during the five-game winning streak. The Patriots have outscored their opponents 175-50 over that span. SportsLine's model says New England covers the spread in more than 50 percent of simulations. The over (44) also cashes more than 50 percent of the time.

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,300 since its inception, and find out.

Steelers vs. Chargers live score, updates, highlights from NFL 'Sunday Night Football' game

Sporting News is tracking live scoring updates and highlights from Steelers vs. Chargers on "Sunday Night Football." Follow for complete results from the NFL Week 11 game.But the Chargers have struggled of late. Last week in a 27-20 loss to the Vikings, Brandon Staley's squad mustered just 253 total yards of offense — the second time in four games they failed to reach the 300 mark. Los Angeles has also a negative point differential, having been outscored 228-219 so far this year.

Week 12 NFL odds, spreads, lines

Sunday, Nov. 28

Titans at Patriots (-7, 43.5)

Jets at Texans (-2.5, 45)

Eagles at Giants (+3.5, 45.5)

Buccaneers at Colts (+3, 53)

Falcons at Jaguars (+2, 46)

Panthers at Dolphins (+2.5, 42)

Steelers at Bengals (-3.5, 44)

Fantasy Football Today: Tracking Week 12 injuries, Thanksgiving players to watch and previewing every game

Before you dig in to a big Thanksgiving meal, make sure your lineups are ready to go with our Week 12 preview newsletterThat starts with my game previews, where I go over every game on the schedule for Week 12, looking at every relevant injury plus my thoughts on every single team. You'll also want to make sure you check out Dave Richard's Starts and Sits, Sleepers and Busts column, where he offers his thoughts on the toughest Fantasy lineup decisions for every game. And Jamey Eisenberg's Start 'Em & Sit 'Em column offers even more lineup advice for you to consume before you consume copious amounts of turkey.

Chargers at Broncos (+2.5, 47)

Vikings at 49ers (-3, 49)

Rams at Packers (+1.5, 47)

Browns at Ravens (-3.5, 47)

Monday, Nov. 29

Seahawks at Washington (PK, 46.5)