World: At least 9 African countries set to produce COVID vaccines, Africa’s CDC chief says

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Why can't African countries distribute vaccines faster? Many countries failed to prepare adequately before receiving the vaccines , Phionah Atuhebwe, from the WHO in Africa , says . "That is one of the reasons we are seeing the slow pace of rollout," she says . South Sudan says in addition to the problem of limited financial A study commissioned by the Africa CDC on Covid -19 vaccine perceptions in 15 countries indicated a significant proportion of people had concerns around vaccine safety. On average, about 20% of respondents said they would not have a vaccine - but the proportion varied

COVID -19 vaccine doesn’t make a difference. Findings from the study showed that increases in coronavirus cases are unrelated to levels of vaccination in the countries and U. S . counties assessed. Most countries rely on vaccines as the primary mitigation strategy to prevent coronavirus infections. Both countries have over 75 percent of their population fully vaccinated . But Iceland and Portugal have also recorded more coronavirus cases per one million people compared to countries with low vaccination rates like South Africa and Vietnam.

As omicron continues to make its impact across the globe, scientists in Africa are rapidly learning more about the new coronavirus variant. Omicron was first identified in southern Africa in November.

A man gets vaccinated against COVID-19 at a site near Johannesburg, Wednesday, Dec. 8, 2021.  © Denis Farrell/AP

A man gets vaccinated against COVID-19 at a site near Johannesburg, Wednesday, Dec. 8, 2021.

Dr. John Nkengasong, the director of Africa Centers for Disease Control and Prevention, told The World's host Carol Hills that so far in South Africa, omicron cases have quickly peaked and declined, with fewer hospitalizations than variants like delta.

"We see omicron as a virus that transmits very, very quickly. But then the severity in South Africa has not been comparable to what we saw with the delta variant," he said.

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Amid a COVID surge in Africa , vaccine promises from richer nations are not enough to bring an early end COVID -19 testing in Johannesburg. South African President Cyril Ramaphosa has reintroduced restrictions At least 20 countries , including Zambia, Uganda, South Africa and the Democratic Republic of However, according to WHO chief scientist Soumya Swaminathan, this could be too late.

The African Union and Africa Centres for Disease Control and Prevention ( Africa CDC ) have voiced "concern" after it emerged that Europe' s digital "green pass" does not recognize a vaccine that was donated to many African countries through the COVAX initiative.

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Africa remains the world’s least vaccinated continent against COVID-19, with about 10% of the continent’s population fully vaccinated. Only seven African countries have met the global target of vaccinating 40% of their populations against COVID-19 by the end of 2021.

However, Nkengasong said Africa's political leadership mounted a "very robust response" early on in the pandemic and that "extraordinary coordination and collaboration" helped to mitigate the impact of COVID-19 in Africa.

Over the last two years, leaders have met to discuss and review pandemic preparedness and response at least 16 times, he said.

Nkengasong joined the The World to discuss several lessons learned so far from studying omicron in southern Africa, as well as from managing the HIV/AIDS pandemic.

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South Africa has started Covid -19 vaccinations following the suspension of an earlier plan to use the Oxford-AstraZeneca vaccine . South Africa is using the Johnson & Johnson vaccine which is administered as a single dose. The country has received 80,000 doses of this vaccine , which has been shown to be effective against the variant first identified in South Africa . President Cyril Ramaphosa says the country has secured nine million doses in total, and more doses are expected.

Supplies to African countries are unlikely to increase much in the next few months, rendering the most effective tool against Covid , vaccines , of little use in the current wave. Instead, many countries are resorting to lockdowns and curfews. Even a year from now, supplies may not be enough to meet demand from Africa ’ s At the current pace of inoculation, only eight small African nations are set to meet a global target to vaccinate at least 10 percent of each country ’s population by September, the W.H.O. says . Vaccine deliveries to Africa are not expected to ramp up until then, according to Covax.

Carol Hills: Dr. Nkengasong, scientists predicted that the African continent will be much harder hit by COVID-19, with tens of millions of infections and several million deaths. That hasn't happened — which is good. But why has the impact been so different than it was predicted?
Dr. John Nkengasong: It is very obvious that through the extraordinary coordination and collaboration that the political leadership of the continent exercised very early on, they were able to mount a very robust response. And just to substantiate that — the political leadership of the continent has met at least 16 times to review the actions and coordinate their efforts and discuss the pandemic — that is highly unusual. In my over three decades experience in public health, we have not seen that.

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On Monday, South African President Cyril Ramaphosa called for an end to vaccine hoarding by wealthier countries as his government scrambled to curb a steep rise in cases. On a continental level, only 40 million doses have been administered so far in Africa - less than 2% of the population, Mr Ramaphosa To address this, he said his government was working with Covax to create a regional hub to produce more vaccines in South Africa . Covax was created last year to ensure Covid -19 doses were made available around the world, with richer countries subsidising costs for poorer nations.

What other factors do you think need to be studied about why Africa didn't see the infections and death levels that were expected, despite the low vaccination rate?
From a scientific perspective, there are several parameters that we need to study in Africa. One is, what are existing immune responses contributing to a less severe outcome? Second, are we counting everybody that has been infected? And have we counted all the deaths? We just concluded a study and we saw that in some countries, the number of people that have been exposed to the virus is significantly higher than what has been reported, but it has not necessarily translated to the number of deaths on the continent, for sure. So then, the research question that we have to resolve is, why has the increased number of exposures on the continent not led to deaths like we saw in India, how devastating the virus was in India — you couldn't hide the deaths, right? But we have not seen that scenario in Africa. We also have to begin to look at the interreaction between existing infections like malaria and even other coronaviruses that cause the common cold in Africa, and if they have led to the production of certain antibodies that can prevent or slow the severity of these diseases. So, a lot that needs to be studied. There are several working groups and research centers across the continent that are looking into this.
I know you've written about the lack of biotech and manufacturing in Africa, and the continent's dependance globally for supplies of vaccines. What steps are being done to change that?
A lot has happened and continues to happen in the course of this pandemic. The heads of states came together and launched a program called Partnership for African Vaccine Manufacturing. And through that partnership, at least nine countries on the continent have engaged in the pathway for producing vaccines, including South Africa, Rwanda, Senegal, Nigeria, Ghana, Morocco, Egypt. Egypt, for example, is already producing about 3.5 million doses of vaccines. We know that South Africa is now producing vaccines. So I think you'll continue to see that the landscape will change significantly in 2022.

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I want to get back to vaccine access because it's such a front-and-center issue. With 10% of the African continent fully vaccinated, what needs to happen to improve access to vaccines?
In 2022, you'll see many more vaccines arrive in the continent, so we have to shift our emphasis on making sure that vaccines that arrive at the airports are actually getting into the arms of people who need it. And that will require that we focus on such capacity for workforce, such capacity for logistics, such capacity for distribution to the last mile, and such capacity to engage the communities. So, those are the key areas that we need to focus on now to increase our uptake of vaccines from the 10% to about over 70% — or more.
President Joe Biden has announced that he intends to nominate you to lead the US president's emergency plan for AIDS relief, known as PEPFAR. Can you speak to how the response to HIV in Africa and worldwide has helped inform the response to COVID?
I think it is important to know that we are dealing with two pandemics across the world. The HIV/AIDS pandemic and COVID[-19] is a pandemic that has just emerged over the last two years. And very unfortunately, and very concerning, is the interreaction of the two pandemics. We now know that people infected with HIV tend to not clear the virus, that is, the COVID-19 virus, appropriately, especially if they have not been fully treated — and that has the risk of creating variants. We don't know what the trajectory for COVID[-19] will look like in the coming years, but we know that HIV has been with us for 40 years [and] has killed almost 37 million people. Tremendous gains have been made in the fight against HIV, especially in Africa. But we should be mindful of what COVID[-19] can do to erode the significant progress that we have made in achieving remarkable progress in controlling HIV/AIDS over the years.
Do you have any predictions or sense of how omicron is going to make its way through the world and its behavior and longevity, based on what happened in Africa? Or is simply more research needed?
I think it's interesting to take a close look at how the trajectory of omicron has been in South Africa. Omicron came in very quickly. We saw it in South Africa rise very sharply to the peak and then decline very quickly. If you compare that to the delta variant, when it first hit South Africa, for example, it took several weeks to peak and then it took several weeks to to begin to decline — which is not the case of omicron. We see omicron as a virus that transmits very, very quickly. But then the severity in South Africa has not been comparable to what we saw with the delta variant. We are truly grateful for that because if the virus had transmitted that quickly and it led to a severity of cases, then it would have been overwhelming completely across southern Africa, and across the world, just because it has now spread across the entire world. So, we continue to learn more about omicron, what we call the pathogenesis and the clinical spectrum of omicron. For example, is it infecting children more? For example, would it lead to long COVID? And what does that mean in terms of the dynamics between omicron and delta variants in South Africa and the world? So there's a lot to be learned from the omicron virus, but at least the early lessons that have emerged is the less severity in terms of clinical outcomes and hospitalization of the omicron variant.

This interview has been lightly edited and condensed for clarity. AP contributed to this report.

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